Tiazac review

Tiazac is a medication containing a calcium channel blocker diltiazem hydrochloride used to treat angina, hypertension and arrhythmia. It works by relaxing blood vessels to lower blood pressure and ease pressure on the heart by decreasing the rate and force of its contraction. It is available in immediate release tablets, extended release capsules and tablets, powder injection, and liquid injection. Although it reduces the risk for angina, do not use Tiazac as a pain relief drug on the onset of angina.

Depending on the condition treated, the dosage may vary from 120mg to 480mg, which may be administered up to 4 times in a day for immediate release tablets. Do not chew the tablets, as it may release the drug all at once. Extended release capsules are taken once a day, preferably at the same time each day. If you have problems swallowing the capsule, ask your doctor if it is advisable to sprinkle its contents along with some soft food such as applesauce. Make sure to rinse your mouth and swallow the rinse to make sure full dosage is administered.

Continue taking the medication even if you feel well, as premature stopping may cause blood pressure to rise again. It may take up to 4 weeks to fully see the effects of the treatment. Do not immediately stop medication as symptoms of your current condition may worsen – consult your doctor to plan the gradual withdrawal of the drug.

Tiazac may not be taken by those with history of certain heart disorders such as AV node conduction disturbances (especially if you do not have a pacemaker), bradycardia, sick sinus syndrome, chronic obstructive pulmonary disease, and Prinzmetal's angina. The drug may aggravate these conditions. Care should also be taken if you have kidney or liver impairment.

Tiazac should also not be taken along with beta-blockers and quinidine as the may have conflicting effects which may lead to dangerous conditions. Also inform your doctor if you are taking any antibiotics, blood pressure drug, or heart medication.

Avoid drinking grapefruit juice when undergoing treatment using Tiazac. Ask your doctor if it is safe to consume grapefruit and grapefruit juice. Avoid drinking alcohol as well as it may further impair your reaction in conjunction with Tiazac.

Tiazac may also cause abnormal results in liver tests, but these return to normal once treatment is over.

Tiazac users may feel constipation, dizziness, nausea, shortness of breath, low blood pressure, rashes and drowsiness among others. You may also experience swelling of hands, legs and feet due to water retention. Some may experience temporary sexual dysfunction, particularly erectile dysfunction. Other more severe effects are abdominal pain, dark colored urine and yellow coloration of skin, fainting and high fever. Consult your doctor if any effect or symptom persist or increase in intensity.

Tiazac should not be given to individuals suffering from heart failure as symptoms may worsen due to the weakening of the heart’s pumping as a result of taking Tiazac.

Tiazac may also increase the amount of liver enzymes in the body, which may be indicative of liver damage. A blood test will be able to detect this condition.

Tiazac has the following structural formula:

Chemical structure of tiazac

• Molecular formula of tiazac is C22H26N2O4S
• Chemical IUPAC Name is [2-(2-dimethylaminoethyl)-5-(4-methoxyphenyl)-3-oxo-6-thia-2-azabicyclo[5.4.0]undeca-7,9,11-trien-4-yl]ethanoate
• Molecular weight is 414.519 g/mol
Tiazac available : 30mg tablets, 60mg tablets, 90mg tablets

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