Tizanidine review

Tizanidine is a centrally acting a-2 adrenergic agonist that is used as a muscle relaxant for the treatment of cramping, tightness of muscles, spasms, and symptoms caused by spastic diplegia, back pain, multiple sclerosis, mild muscle pain, or grievous injuries to the spine or central nervous system. This medication's off-label uses include seizure inhibition, sleeping aid, and treatment of several fibromyalgia symptoms.

Take this medication as directed by your doctor and follow his or her directions exactly. Your daily dosage will probably need some adjustment by your doctor at first in order to achieve the desired effect. A single eight milligram dose reduces muscle tone in patients with spasticity for a couple of hours. It peaks at around one or two hours and dissipates after three to six hours. Doses can be repeated at six to eight hour intervals as needed.

Food can also be a factor in changing the way your body absorbs this medication, so make sure to talk about this with your doctor to resolve the best way to take your dose. After all, changes to your dose may be considered depending on your metabolism, and the dose form of tizanidine—tablet or capsule—are factors for consideration as well.

Before undergoing tizanidine treatment, consult with your doctor if you have any allergies with this medication or any other medication, liver or heart disease, low blood pressure, eye disease, or kidney disease. Prudence and carefulness should also be observed when this drug is used on the elderly.

Also be warned that alcohol may intensify the dizziness and drowsiness side effect found in taking this drug, so you should limit alcohol intake during treatment. On that note, since this medicine can cause low alertness due to the aforementioned side effects, be careful when driving, operating heavy machinery, or doing whatever task that requires your full attention, concentration, and alertness.

Tizanidine use isn't outright banned when you're pregnant, but it should only be used when clearly needed. You also need to discuss the pros and cons of using tizanidine during pregnancy with your designated healthcare professional. It is still unknown whether it passes into human milk, so err on the side of caution and avoid using this drug when breastfeeding. On the other hand, if you really do need to breastfeed while under tizanidine treatment, consult your doctor promptly.

If you've been under tizanidine treatment for a long period of time, do not suddenly taking this drug without due medical consultation. Some diseases, maladies, and conditions may worsen when this drug is suddenly halted, so your dose may need to be gradually lessened to prevent any unnecessary complications.

Do not double up your dose to catch up a missed dose; just take it as soon as your remember. If it is near the time of the next dose, just skip the missed dose and continue your regular dosing regimen.

When taking tizanidine, there's a chance that constipation, unusual weakness, drowsiness, nausea, or dry mouth may occur. If such symptoms endure or worsen, report this information to your doctor quickly. In order to minimize the dizziness side effect, you must rise up slowly when getting up from a sitting or prone position. Don't forget to notify your doctor if you develop yellowing skin and eyes, vomiting, hallucinations, and stomach pain.

Tizanidine has the following structural formula:

Chemical structure of tizanidine

• Molecular formula of tizanidine is C9H8ClN5S
• Chemical IUPAC Name is 4-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-8-thia-7,9- diazabicyclo[4.3.0]nona-2,4,6,9-tetraen-5-amine
• Molecular weight is 253.712 g/mol
Tizanidine available : 2mg capsules, 4mg capsules, 6mg capsules, 2mg tablets, 4mg tablets

Brand name(s): Pramiracetam, Sirdalud, Ternelin, Tizanidina, Tizanidinum, Zanaflex

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