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Tolbutamide

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Tolbutamide

Tolbutamide review





Tolbutamide is an anti-diabetic drug that is used in patients with non-insulin dependent diabetes (NIDDM) or adult maturity onset diabetes. Taking this medication lowers blood sugar levels by promoting the creation and release of insulin from the pancreas and also encouraging the transfer of sugar from the blood into the cells in the body that need it. These two benefits, in combination with a diet that is low in sugar and fat, allow diabetics to manage their blood sugar levels more efficiently.

Take this medicine as exactly prescribed by your healthcare specialist. Don't hesitate to ask your pharmacist, nurse, or doctor if you cannot understand certain parts of the given instructions. Moreover, take each dose of the drug with a full glass—about eight ounces—of water. Tolbutamide is usually taken before the first main meal, breakfast or otherwise, if it is taken once a day, or before meals if it's taken more than once a day. It is crucial to take this medication as regularly as possible to get the most therapeutic benefits.

Cease tolbutamide treatment and seek immediate emergency medical attention if you experience an allergic reaction to the drug. Symptoms of allergy include the hives, closing of the throat, difficulty in breathing, and swelling of the tongue, lips, or face.

You should not take this medication—or you may need to make a dosage alteration and have special monitoring during tolbutamide therapy—if you have any of these conditions: kidney disease, liver disease, thyroid disease, type-1 diabetes, a serious infection, illness, injury, or have a condition that requires surgery. In addition, patients who are sixty-five years of age or older may have a more powerful reaction to the drug and may need a lesser dosage.

Tolbutamide is within FDA pregnancy category C, which means that it is dangerous to the unborn baby. This drug should also be avoided during the first trimester of pregnancy, because it may produce birth defects or teratogenesis. Mothers should not take this drug without first consulting their respective doctors about the risks, especially if they are pregnant or plan to be pregnant during treatment. They will probably be prescribed insulin instead, because that is the medication of choice for treating diabetes during pregnancy.

As an additional precaution, this drug also passes into breast milk and may cause hypoglycemia (low blood sugar) to a nursing baby. Breastfeeding mothers should not use tolbutamide. Again, inform your doctor first before taking this medicine if you are currently breastfeeding a baby.

Lastly, intake of excessive amounts of alcohol is discouraged while taking this medication. In turn, your blood sugar levels should be monitored frequently when under tolbutamide treatment in order to avoid complications involving low blood sugar.

The other most common side effects of tolbutamide mostly root from blood sugar levels becoming too high (from missed tolbumatide doses or excessive food intake) or too low (from tolbutamide overdose). Diabetics should be familiar with the symptoms of both high blood sugar levels (excessive thirst, hunger, and urination) and low blood sugar levels (shaking, headache, clammy skin, and difficulty in concentrating) and know how to treat both conditions. Just be sure close friends and family are nearby and know how to help you during such emergencies.

Tolbutamide has the following structural formula:

Chemical structure of tolbutamide


• Molecular formula of tolbutamide is C12H18N2O3S
• Chemical IUPAC Name is 1-butyl-3-(4-methylphenyl)sulfonylurea

Brand name(s): Aglicid, Arkozal, Artosin, Artozin, Butamid, Butamide, Diaben, Diabetamid, Diabetol, Diabuton, Diasulfon, Dirastan, Dolipol, Drabet, Glyconon, Ipoglicone, Mobenol, Orabet, Oralin, Orezan, Orinase, Orinaz, Oterben, Pramidex, Rastinon, Restinon, Tol-Tab, Tolbusal, Tolbutamid, Toluina, Tolumid, Toluvan, Willbutamide

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