Trevilor review

Trevilor used to be one of the top six antidepressant drugs in America. It belongs to a class known as SNRIs with direct actions on various neurotransmitters. However, there are associated risks involved which should be taken seriously by all consumers.

Trevilor is the brand name of the generic antidepressant drug venlafaxine. It is used as an alternative to Effexor which acts on neurotransmitters in the brain. Trevilor affects the production and action of serotonin, dopamine and norepinephrine which are responsible for mood. Mainly, the drug is used to treat depression including cases with symptoms like anxiety, social anxiety disorder, panic disorder and generalized anxiety disorder.

The pharmaceutical company, Wyeth first introduced the drug in 1993 wherein it was labeled under the class of serotonin-norepinephrine reuptake inhibitors or SNRIs. Due to a number of dangerous side effects however, Trevilor is not immediately recommended for depression treatment. It is usually used when SSRI medications do not work too well. The drug used to be one of the most widely used antidepressants in the United States.

Other off-label uses of Trevilor include treatment of diabetic neuropathy wherein it acts similarly as duloxetine. It was also shown effective in migraine prophylaxis and alleviation of hot flushes in menopausal women. Venlafaxine hydrochloride belongs to the phenylthylamine class of modern chemicals.

Like all drugs, Trevilor also has a variety of known side effects. Common ones include nausea, headache, constipation, dizziness, fatigue, vertigo, dry mouth, sexual dysfunction, irritable bowel syndrome, insomnia, apathy, sweating, amnesia, hypertension and poor appetite. Uncommon ones include abnormal vision, suicidal ideations, loss of appetite, stomach pain, drowsiness and cardiac arrhythmia. Rare symptoms include external bleeding, alopecia, aggression, homicidal ideations, hepatitis, pancreatitis and visual hallucinations.

Trevilor is contraindicated in patients with known hypersensitivity to the drug. People with liver, thyroid and kidney problems should also stay clear. The drug can cause increased eye pressure so those with glaucoma will need their doctor’s recommendations. Pregnant women and breastfeeding mothers need to check first if it is safe to take the drug. Patients suffering from heart disease and high blood pressure are not allowed to take Trevilor since it may lead to persistent pulmonary hypertension. Those under Effexor XR treatment as well as those taking serotonergic drugs need to be careful to avoid serotonin syndrome.

Trevilor is metabolized in the liver before being absorbed in the bloodstream. The drug directly acts on receptor sites that bind the neurotransmitters dopamine, norepinephrine and serotonin. As a result, chemical messenger levels in the brain will be normalized. Serotonin and dopamine levels in particular will be released and accumulate well causing an improvement in mood and overall sense of well-being.

A group of 21 patients were given 75 mg of Trevilor once daily for 6 weeks. By the second week, 18 patients improved significantly in terms of mood. By the third week, all patients had a satisfying sense of well-being. The trial was done only on patients who did not respond well to SSRIs. 18 out of the 21 individuals presented symptoms like poor appetite, hypertension and insomnia including 5 who presented suicidal ideations.

The drug is available in many pharmacies and doctor’s clinic. It comes in 37.5 mg and 75 mg capsules or tablets. Check for existence of address and telephone number when buying online.

Trevilor should be taken with food. Dosage should always be indicated by a physician which can vary depending on the individual. Discontinuation of the drug should be gradual to avoid mild symptoms.

Trevilor has the following structural formula:

Chemical structure of trevilor

• Molecular formula of trevilor is C17H27NO2
• Chemical IUPAC Name is 1-[2-dimethylamino-1-(4-methoxyphenyl)-ethyl]cyclohexan-1-ol
• Molecular weight is 277.402 g/mol
Trevilor available : 37,5mg tablets

Generic name: Venlafaxine

Brand name(s): Effexor, Effexor XR, Elafax, Venlafaxina, Venlafaxinum

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