Trimethoprim review

A bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections, trimethoprim (INN) belongs to the family of chemotherapeutic agents known as dihydorfolate reductase inhibitors. It used to be marketed by GlaxoSmithKline under the trade names of Triprim, Monotrim, and Proloprim, but eventually, these three brands were licensed to various generic pharmaceutical manufacturers. Often abbreviated to TRI or TMP in clinical use, trimethoprim's common laboratory abbreviation is W.

The recommended daily oral dosage for trimethoprim is 100 milligrams every twelve hours twice daily or 200 milligrams trimethoprim (that is, two 100 milligram tablets) once daily, both for ten days. The use of trimethoprim in patients with a creatinine clearance of less than fifteen milliliters per minute is not advisable. As for patients with a creatinine clearance of fifteen to thirty milliliters per minute, the does should be fifty milligrams every twelve hours twice daily.

It is essential that you finish the prescribed course of this antibiotic medicine if you lready feel better or it seems that the infection has cleared up unless your doctor tells you otherwise. Halting the treatment early increases your risk of having your infection suddenly relapse or worsen, plus there's a chance that the bacteria will grow resistant to trimethoprim in the long run.

Trimethoprim should not be taken if you are allergic to it or any of its ingredients. Immediately consult your pharmacist or doctor if you have previously experience such an allergy. Likewise, if you feel you have experienced an allergic reaction while undergoing trimethoprim treatment, then you must promptly halt therapy and contact your designated healthcare specialist as soon as possible.

Infrequently, trimethoprim can decrease the normal levels of blood cells in your blood. As such, you should inform you doctor immediately if you experience any of the subsequent symptoms because these may indicate a lowered blood cell malady: feeling tired or general illness, high temperature fever, mouth ulcers, sore throat, purple spots, and unexplained bruising or bleeding. Your physician may have to give you a blood examination in order to check your blood cell count.

Be warned that this drug may rarely cause acute skin rashes that may be fatal and need emergency medical treatment in the hospital. As always, you must report to you doctor immediately if you suddenly develop itching, skin blistering, peeling, itching, a rash, or other inexplicable skin conditions while taking this antibiotic.

Other possible side effects to look out for include erythema multiforme, toxic epidermal necrolysis, photosensitivity or abnormal reaction of your skin to light that usually results in a rash, disturbance in the production of blood cells, increase in the level of potassium in the blood or hyperkalaemia, itching or pruritus, nausea, and vomiting.

Finally, you should take to heart that the side effects listed in this drug review may not include all of the side effects reported by this medication's manufacturer. Therefore, if you want to get more information about any other possible risks connected with trimethoprim, please read carefully the information provided with the medicine or consult your doctor or pharmacist.

Trimethoprim has the following structural formula:

Chemical structure of trimethoprim

• Molecular formula of trimethoprim is C14H18N4O3
• Chemical IUPAC Name is 5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine
• Molecular weight is 290.318 g/mol
Trimethoprim available : 100mg tablets

Brand name(s): Abacin, Abaprim, Alprim, Apo-Sulfatrim, Bactin, Bactramin, Bactrim, Bactrim Ds, Baktar, Chemotrim, Co-trimoxazole, Comox, Cotrim, Drylin, Eusaprim, Fectrim, Gantaprim, Gantrim, Idotrim, Imexim, Instalac, Ipral, Kepinol, Laratrim, Lidaprim, Linaris, Methoprim, Microtrim, Monoprim, Monotrim, Monotrimin, Nopil, Oraprim, Priloprim, Primosept, Primsol, Proloprim, Septra, Septra Ds, Septrin, Sigaprim, Sulfamethoprim, Sulfatrim, Sulfatrim-Ds, Sulfatrim-Ss, Sulfotrim, Sulmeprim, Sulprim, Sumetrolim, Supracombin, Suprim, Syraprim, Teleprim, Thiocuran, Tiempe, Trigonyl, Trimanyl, Trimesulf, Trimethioprim, Trimethopriom, Trimetoprim, Trimexazole, Trimogal, Trimopan, Trimpex, Triprim, Unitrim, Uretrim, Uro-Septra, Uroplus, Uroplus Ds, Uroplus Ss, Veltrim, Wellcoprim

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