Vidaza review

Vidaza is used to treat myelodysplastic syndrome (MDS), a type of bone marrow disease that typically precedes leukemia, and its subtypes such as various refractory anemia, including those with ringed sideroblasts, excess blasts, and excess blasts in transformation. MDS is caused by the improper functioning of the bone marrow. When bone marrow cells are deformed, this causes a decrease in blood production. It is also used in the treatment of some leukemia such as chronic myelomonocytic leukemia, refractory acute lymphocytic leukemia and refractory acute myelogenous leukemia

Vidaza improves the bone marrow function by binding to the DNA and Ribonucleic acid, and improving blood production by killing off abnormal cells. In a study done on Vidaza use, patients that previously needed blood transfusions for MDS no longer needed it after being treated with Vidaza, and 16% reported full return of bone marrow structure and blood cell count.

Vidaza is available as a powder, readily soluble in water and can be administered subcutaneously or intravenously by a physician or nurse. Treatment is typically a once-a-day injection for seven days, and may be repeated after 4 weeks. Physicians typically prescribe 4 treatments at a time. Doses may be increased after two cycles if significant improvement is not evident and no adverse side effects are seen. Alternatively, subsequent treatments may be delayed or dosages reduced if negative side effects are evident. It is important to communicate with your physician regarding any symptoms felt while undergoing treatment. The dosage is dependent on the patient's weight, previous treatment history and other assessments made by your physician. The physician may also use Vidaza in other related cases if found to work effectively.

Known side effects may include nausea, diarrhea or constipation, mouth sores, tiredness, cramps, back and joint pain, perspiration, skin edema of ankles, hands and feet, rashes and reddening of skin and weakness. If you experience any of these symptoms, consult your physician.

A low white blood count may be experienced in between sessions. During this period you may be susceptible to infections. This low point is temporary, lasting usually 10-17 days but possibly taking 28-31 days to recover.

Serious side effects that require immediate medical attention include pale skin, rapid heartbeat, chest pains, bruising or bleeding, epistaxis, signs of infection such as a fever and sore throat, and red or purple dots on the skin. Consult your physician immediately if any of these symptoms occur.

Make certain your physician is aware of any medications that you are currently taking as well as any medication allergies you have. Also, avoid taking aspirin while undergoing treatment unless your physician specifically allows this.

Do not take any form of immunization such as vaccines while on Vidaza. The lowered white blood cell count may leave you in danger.

Women who are pregnant or plan to become pregnant as well as women who are breastfeeding need to consult their doctor before taking this medication. Vidaza may be harmful to a developing fetus and may also affect fertility if you are planning to become pregnant. Avoid breastfeeding while on this medication.

Contraceptives may also interact with the medication so use of barrier methods such as condoms are advised while taking this medication. Consult your physician for more information.

Vidaza has the following structural formula:

Chemical structure of vidaza

• Molecular formula of vidaza is C8H12N4O5
• Chemical IUPAC Name is 4-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one
• Molecular weight is 244.205 g/mol
Vidaza available : 100mg tablets

Generic name: Azacitidine

Brand name(s): Azacitidina, Azacitidinum, Azacytidine, Ladakamycin, Mylosar

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