Zerit is generically prescribed as stavudine and is commonly used to inhibit the HIV virus from reproducing in the body of an HIV positive patient. Zerit is not a cure for HIV and the virus can still be passed from person to person even with drug therapy.
Zerit has been associated with severe liver complications and a condition known as lactic acidosis, both of which can be fatal. Patients should be instructed to seek immediate emergency medical attention should they experience symptoms, even mild ones, such as nausea, vomiting, unusual and unexpected stomach pain, shortness of breath, fatigue, weakness in the extremities, jaundice, or pain in the upper abdomen or stomach as these can be early warning signs of either liver failure or lactic acidosis.
Zerit is not appropriate for all patients. A thorough assessment of a patient’s current state of health and medical history is necessary prior to prescribing this medication. Patients with a medical history or current health condition which includes liver disease, kidney disease, pancreatitis, or numbness and tingling of the extremities may not be able to undergo drug therapy with Zerit or may require additional monitoring while taking this medication, depending on the condition and its severity.
The American Food and Drug Administration rated Zerit as a pregnancy risk category C. It has yet to be determined whether or not Zerit will cause harm or birth defects in unborn babies. It also has not yet been determined whether or not Zerit will pass through the mother’s breast milk and cause ill effects to a nursing baby. The prescribing physician should not administer a prescription for Zerit to a woman who is pregnant, may become pregnant, or is nursing without first seriously discussing whether or not the benefits outweigh the risks. Women with HIV and AIDS are discouraged from breast feeding their babies to inhibit the transmission of the disease.
There is a possibility of experiencing serious side effects while taking Zerit. Allergic reactions and other significant side effects require immediate emergency medical attention. Hives, difficulty breathing, facial swelling, swelling of the lips, tongue, throat, or mouth are all symptoms of an allergic reaction. Other serious side effects may include nausea, vomiting, stomach pain, weakness, tiredness, shortness of breath, weakness of the extremities, jaundice (yellowing of the skin or eyes), pale skin, or pain in the upper abdominal region.
Less serious side effects generally require no medical attention and may be alleviated by adjusting the dose of Zerit. Less serious side effects should be reported to the prescribing physician and may include headaches, fever, chills, nausea, vomiting, diarrhea, rash, decrease in appetite, insomnia, or a change in the body’s composition of body fat.
Zerit should only be taken as it has been prescribed by the physician. If the patient misses a regularly scheduled dose of Zerit, it can be made up at the next earliest convenience. If it is almost time for the next dose of Zerit, the missed dose should be skipped altogether. Taking more than has been prescribed can result in an overdose which will require urgent medical assessment. An overdose may present with liver damage which includes jaundice, nausea, vomiting, abdominal pain, severe fatigue, and easy bruising or bleeding), numbness, tingling, or generalized pain in any part of the body.
Drug interactions should be avoided and the prescribing physician should maintain a record of all current medications. Patients should always inquire with the prescribing physician or pharmacist before taking any new medications, including over the counter drugs and herbal remedies. Medications with known interactions with Zerit include dapsone, phenytoin, chloramphenicol, cisplatin, didanosine, ethambutol, hydralazine, lithium, metronidazole, nitrofurantoin, vincristine, zalcitabine, and zidovudine.
Zerit has the following structural formula:
• Molecular formula of zerit is C10H12N2O4
• Chemical IUPAC Name is 1-[5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione
• Molecular weight is 224.213 g/mol
• Zerit available : 15mg capsules, 20mg capsules, 30mg capsules, 40mg capsules, 1mg/ml solution 200ml bottle
Generic name: Stavudine
Brand name(s): Ddethd, Ddetyd, Estavudina, Sanilvudine, Stavudinum, Zerit Xr, Zerut Xr
Review published on: 07 June 2007
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